FOXO3 (Forkhead box protein O3) variants and mutations

FOXO3 (also known as Forkhead box protein O3) is a human protein-coding gene encoding a forkhead box protein O3 protein. It activates stress-resistance, autophagy, cell-cycle arrest, and apoptotic programs when growth-factor signaling is low. Variation near FOXO3 has repeatedly been associated with human longevity, while altered activity influences cancer and metabolic disease. This analysis covers 1,256 FOXO3 variants and mutations. Of these, 93% have computational variant effect predictions. Disease context includes Alzheimer disease, intelligence, and neurodegenerative disease. Example FOXO3 variants include A2E, A2T, and A2V.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable FOXO3 variants

Examples include A2E, A2T, A2V, A2S, A2A, E3*, E3V, A4R. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.