E15K (p.Glu15Lys) variant of FOXO3 (Forkhead box protein O3)
E15K (p.Glu15Lys) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data, published literature, and structural context.
E15K (p.Glu15Lys) variant details
- p.Glu15Lys
- gnomAD 6-108561251-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.368
- REVEL 0.27
- MetaLR 0.29
- MetaSVM -0.75
- CADD 23.90
- PolyPhen-2 0.00
- SIFT 0.08
- Most common in the Non-Finnish European population (allele frequency 9.2e-07)
- Structural context available
- Literature evidence available