R37M (p.Arg37Met) variant of FOXO3 (Forkhead box protein O3)
R37M (p.Arg37Met) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.71 / 1. The record also includes population frequency data, published literature, and structural context.
R37M (p.Arg37Met) variant details
- p.Arg37Met
- gnomAD 6-108561318-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.712
- REVEL 0.69
- MetaLR 0.73
- MetaSVM 0.59
- CADD 26.20
- PolyPhen-2 0.54
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9.2e-07)
- Structural context available
- Literature evidence available