L11F (p.Leu11Phe) variant of FOXO3 (Forkhead box protein O3)
L11F (p.Leu11Phe) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
L11F (p.Leu11Phe) variant details
- p.Leu11Phe
- TOPMed rs1342949133
- Missense
- Variant Prioritization Score for Impact Estimate 0.382
- REVEL 0.33
- MetaLR 0.44
- MetaSVM -0.43
- CADD 17.60
- PolyPhen-2 0.34
- SIFT 0.06
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available