P20S (p.Pro20Ser) variant of FOXO3 (Forkhead box protein O3)
P20S (p.Pro20Ser) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data, published literature, and structural context.
P20S (p.Pro20Ser) variant details
- p.Pro20Ser
- gnomAD 6-108561266-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.53
- REVEL 0.44
- MetaLR 0.54
- MetaSVM -0.02
- CADD 23.30
- PolyPhen-2 0.10
- SIFT 0.05
- Most common in the Non-Finnish European population (allele frequency 9.2e-07)
- Structural context available
- Literature evidence available