P20T (p.Pro20Thr) variant of FOXO3 (Forkhead box protein O3)
P20T (p.Pro20Thr) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data, published literature, and structural context.
P20T (p.Pro20Thr) variant details
- p.Pro20Thr
- gnomAD 6-108561266-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.505
- REVEL 0.39
- MetaLR 0.57
- MetaSVM -0.00
- CADD 23.00
- PolyPhen-2 0.01
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9.2e-07)
- Structural context available
- Literature evidence available