S12Y (p.Ser12Tyr) variant of FOXO3 (Forkhead box protein O3)
S12Y (p.Ser12Tyr) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data, published literature, and structural context.
S12Y (p.Ser12Tyr) variant details
- p.Ser12Tyr
- gnomAD 6-108561243-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.465
- REVEL 0.34
- MetaLR 0.36
- MetaSVM -0.27
- CADD 23.30
- PolyPhen-2 0.16
- SIFT 0.02
- Population evidence available
- Structural context available
- Literature evidence available