E39D (p.Glu39Asp) variant of FOXO3 (Forkhead box protein O3)
E39D (p.Glu39Asp) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
E39D (p.Glu39Asp) variant details
- p.Glu39Asp
- TOPMed rs1246903417
- gnomAD rs1246903417
- Missense
- Variant Prioritization Score for Impact Estimate 0.355
- REVEL 0.23
- MetaLR 0.31
- MetaSVM -0.70
- CADD 17.00
- PolyPhen-2 0.00
- SIFT 0.37
- Most common in the Non-Finnish European population (allele frequency 4.4e-05)
- Structural context available