P10L (p.Pro10Leu) variant of FOXO3 (Forkhead box protein O3)
P10L (p.Pro10Leu) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data and structural context.
P10L (p.Pro10Leu) variant details
- p.Pro10Leu
- ExAC rs755477843
- TOPMed rs755477843
- gnomAD rs755477843
- Missense
- Variant Prioritization Score for Impact Estimate 0.277
- REVEL 0.18
- MetaLR 0.36
- MetaSVM -0.63
- CADD 20.20
- PolyPhen-2 0.00
- SIFT 0.08
- Most common in the REMAINING population (allele frequency 0.00014)
- Structural context available