R29L (p.Arg29Leu) variant of FOXO3 (Forkhead box protein O3)
R29L (p.Arg29Leu) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.81 / 1. The record also includes population frequency data, published literature, and structural context.
R29L (p.Arg29Leu) variant details
- p.Arg29Leu
- gnomAD 6-108561294-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.807
- REVEL 0.81
- MetaLR 0.89
- MetaSVM 0.97
- CADD 28.80
- PolyPhen-2 0.97
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- Literature evidence available