L35M (p.Leu35Met) variant of FOXO3 (Forkhead box protein O3)
L35M (p.Leu35Met) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data, published literature, and structural context.
L35M (p.Leu35Met) variant details
- p.Leu35Met
- gnomAD 6-108561311-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.379
- REVEL 0.32
- MetaLR 0.53
- MetaSVM -0.37
- CADD 22.50
- PolyPhen-2 0.01
- SIFT 0.01
- Population evidence available
- Structural context available
- Literature evidence available