P13L (p.Pro13Leu) variant of FOXO3 (Forkhead box protein O3)
P13L (p.Pro13Leu) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data, published literature, and structural context.
P13L (p.Pro13Leu) variant details
- p.Pro13Leu
- gnomAD 6-108561246-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.408
- REVEL 0.23
- MetaLR 0.40
- MetaSVM -0.38
- CADD 22.00
- PolyPhen-2 0.00
- SIFT 0.04
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available