S30Y (p.Ser30Tyr) variant of FOXO3 (Forkhead box protein O3)
S30Y (p.Ser30Tyr) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.72 / 1. The record also includes population frequency data, published literature, and structural context.
S30Y (p.Ser30Tyr) variant details
- p.Ser30Tyr
- gnomAD 6-108561297-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.719
- REVEL 0.69
- MetaLR 0.80
- MetaSVM 0.76
- CADD 24.70
- PolyPhen-2 0.60
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9.2e-07)
- Structural context available
- Literature evidence available