S12P (p.Ser12Pro) variant of FOXO3 (Forkhead box protein O3)
S12P (p.Ser12Pro) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data, published literature, and structural context.
S12P (p.Ser12Pro) variant details
- p.Ser12Pro
- gnomAD 6-108561242-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.42
- REVEL 0.37
- MetaLR 0.29
- MetaSVM -0.67
- CADD 18.40
- PolyPhen-2 0.00
- SIFT 0.42
- Most common in the African/African-American population (allele frequency 3.2e-05)
- Structural context available
- Literature evidence available