R27C (p.Arg27Cys) variant of FOXO3 (Forkhead box protein O3)
R27C (p.Arg27Cys) in FOXO3 (Forkhead box protein O3) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.78 / 1. The record also includes structural context.
R27C (p.Arg27Cys) variant details
- p.Arg27Cys
- rs909124051
- ClinGen CA365337002
- ClinVar RCV004160419
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.779
- AlphaMissense 1.00
- MetaLR 0.75
- MetaSVM 0.72
- PolyPhen-2 0.57
- SIFT 0.00
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available