L14F (p.Leu14Phe) variant of FOXO3 (Forkhead box protein O3)
L14F (p.Leu14Phe) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
L14F (p.Leu14Phe) variant details
- p.Leu14Phe
- TOPMed rs1164825807
- Missense
- Variant Prioritization Score for Impact Estimate 0.402
- REVEL 0.27
- MetaLR 0.44
- MetaSVM -0.40
- CADD 20.60
- PolyPhen-2 0.45
- SIFT 0.09
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available