R29Q (p.Arg29Gln) variant of FOXO3 (Forkhead box protein O3)
R29Q (p.Arg29Gln) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.79 / 1. The record also includes population frequency data, published literature, and structural context.
R29Q (p.Arg29Gln) variant details
- p.Arg29Gln
- gnomAD 6-108561294-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.792
- REVEL 0.78
- MetaLR 0.89
- MetaSVM 0.97
- CADD 29.10
- PolyPhen-2 0.95
- SIFT 0.00
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available
- Literature evidence available