L18Q (p.Leu18Gln) variant of FOXO3 (Forkhead box protein O3)
L18Q (p.Leu18Gln) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data and structural context.
L18Q (p.Leu18Gln) variant details
- p.Leu18Gln
- TOPMed rs1775775867
- gnomAD rs1775775867
- Missense
- Variant Prioritization Score for Impact Estimate 0.487
- REVEL 0.45
- MetaLR 0.45
- MetaSVM -0.27
- CADD 23.80
- PolyPhen-2 0.28
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available