A2E (p.Ala2Glu) variant of FOXO3 (Forkhead box protein O3)
A2E (p.Ala2Glu) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data and structural context.
A2E (p.Ala2Glu) variant details
- p.Ala2Glu
- gnomAD rs1775773594
- Missense
- Variant Prioritization Score for Impact Estimate 0.561
- REVEL 0.48
- MetaLR 0.59
- MetaSVM 0.12
- CADD 23.70
- PolyPhen-2 0.20
- SIFT 0.05
- Most common in the South Asian population (allele frequency 0.00021)
- Structural context available