L14I (p.Leu14Ile) variant of FOXO3 (Forkhead box protein O3)
L14I (p.Leu14Ile) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data, published literature, and structural context.
L14I (p.Leu14Ile) variant details
- p.Leu14Ile
- gnomAD 6-108561248-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.346
- REVEL 0.19
- MetaLR 0.40
- MetaSVM -0.50
- CADD 18.60
- PolyPhen-2 0.11
- SIFT 0.04
- Population evidence available
- Structural context available
- Literature evidence available