P20L (p.Pro20Leu) variant of FOXO3 (Forkhead box protein O3)
P20L (p.Pro20Leu) in FOXO3 (Forkhead box protein O3) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.66 / 1. The record also includes population frequency data and structural context.
P20L (p.Pro20Leu) variant details
- p.Pro20Leu
- gnomAD rs1266847313
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.66
- REVEL 0.65
- MetaLR 0.59
- MetaSVM 0.34
- CADD 24.20
- PolyPhen-2 0.21
- SIFT 0.02
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the African/African-American population (allele frequency 3.1e-05)
- Structural context available