K46R (p.Lys46Arg) variant of FOXO3 (Forkhead box protein O3)
K46R (p.Lys46Arg) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data, published literature, and structural context.
K46R (p.Lys46Arg) variant details
- p.Lys46Arg
- gnomAD 6-108561345-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.389
- REVEL 0.27
- MetaLR 0.43
- MetaSVM -0.37
- CADD 23.10
- PolyPhen-2 0.03
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available
- Literature evidence available