R27G (p.Arg27Gly) variant of FOXO3 (Forkhead box protein O3)
R27G (p.Arg27Gly) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.70 / 1. The record also includes population frequency data and structural context.
R27G (p.Arg27Gly) variant details
- p.Arg27Gly
- gnomAD rs909124051
- Missense
- Variant Prioritization Score for Impact Estimate 0.697
- REVEL 0.65
- AlphaMissense 1.00
- MetaLR 0.75
- MetaSVM 0.72
- CADD 23.90
- PolyPhen-2 0.57
- Most common in the HGDP:BANTUKENYA population (allele frequency 0.11)
- Structural context available