A2T (p.Ala2Thr) variant of FOXO3 (Forkhead box protein O3)
A2T (p.Ala2Thr) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data and structural context.
A2T (p.Ala2Thr) variant details
- p.Ala2Thr
- gnomAD rs1175724154
- Missense
- Variant Prioritization Score for Impact Estimate 0.558
- REVEL 0.46
- MetaLR 0.60
- MetaSVM 0.18
- CADD 24.50
- PolyPhen-2 0.32
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 8.5e-05)
- Structural context available