L18M (p.Leu18Met) variant of FOXO3 (Forkhead box protein O3)
L18M (p.Leu18Met) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data, published literature, and structural context.
L18M (p.Leu18Met) variant details
- p.Leu18Met
- gnomAD 6-108561260-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.368
- REVEL 0.25
- MetaLR 0.44
- MetaSVM -0.29
- CADD 22.60
- PolyPhen-2 0.22
- SIFT 0.00
- Population evidence available
- Structural context available
- Literature evidence available