E21G (p.Glu21Gly) variant of FOXO3 (Forkhead box protein O3)
E21G (p.Glu21Gly) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data, published literature, and structural context.
E21G (p.Glu21Gly) variant details
- p.Glu21Gly
- gnomAD 6-108561270-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.417
- REVEL 0.38
- MetaLR 0.43
- MetaSVM -0.14
- CADD 24.70
- PolyPhen-2 0.04
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 9.2e-07)
- Structural context available
- Literature evidence available