A45T (p.Ala45Thr) variant of FOXO3 (Forkhead box protein O3)
A45T (p.Ala45Thr) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data, published literature, and structural context.
A45T (p.Ala45Thr) variant details
- p.Ala45Thr
- gnomAD 6-108561341-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.407
- REVEL 0.23
- MetaLR 0.39
- MetaSVM -0.53
- CADD 21.40
- PolyPhen-2 0.03
- SIFT 0.08
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available