S12C (p.Ser12Cys) variant of FOXO3 (Forkhead box protein O3)
S12C (p.Ser12Cys) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
S12C (p.Ser12Cys) variant details
- p.Ser12Cys
- gnomAD rs1250726678
- Missense
- Variant Prioritization Score for Impact Estimate 0.464
- REVEL 0.33
- MetaLR 0.37
- MetaSVM -0.28
- CADD 23.50
- PolyPhen-2 0.21
- SIFT 0.01
- Most common in the Latino/Admixed American population (allele frequency 2.6e-05)
- Structural context available