Q25R (p.Gln25Arg) variant of FOXO3 (Forkhead box protein O3)
Q25R (p.Gln25Arg) in FOXO3 (Forkhead box protein O3) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
Q25R (p.Gln25Arg) variant details
- p.Gln25Arg
- TOPMed rs1223937209
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.458
- REVEL 0.39
- MetaLR 0.54
- MetaSVM -0.04
- CADD 23.70
- PolyPhen-2 0.14
- SIFT 0.04
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available