F22L (p.Phe22Leu) variant of FOXO3 (Forkhead box protein O3)
F22L (p.Phe22Leu) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data, published literature, and structural context.
F22L (p.Phe22Leu) variant details
- p.Phe22Leu
- gnomAD 6-108561272-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.506
- REVEL 0.43
- MetaLR 0.65
- MetaSVM 0.30
- CADD 24.50
- PolyPhen-2 0.07
- SIFT 0.00
- Population evidence available
- Structural context available
- Literature evidence available