A42V (p.Ala42Val) variant of FOXO3 (Forkhead box protein O3)
A42V (p.Ala42Val) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data, published literature, and structural context.
A42V (p.Ala42Val) variant details
- p.Ala42Val
- gnomAD 6-108561333-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.37
- REVEL 0.22
- MetaLR 0.37
- MetaSVM -0.57
- CADD 22.20
- PolyPhen-2 0.00
- SIFT 0.10
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available