L11V (p.Leu11Val) variant of FOXO3 (Forkhead box protein O3)
L11V (p.Leu11Val) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data, published literature, and structural context.
L11V (p.Leu11Val) variant details
- p.Leu11Val
- gnomAD 6-108561239-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.356
- REVEL 0.31
- MetaLR 0.36
- MetaSVM -0.55
- CADD 15.30
- PolyPhen-2 0.06
- SIFT 0.17
- Most common in the East Asian population (allele frequency 2.7e-05)
- Structural context available
- Literature evidence available