P24L (p.Pro24Leu) variant of FOXO3 (Forkhead box protein O3)
P24L (p.Pro24Leu) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.81 / 1. The record also includes population frequency data, published literature, and structural context.
P24L (p.Pro24Leu) variant details
- p.Pro24Leu
- gnomAD 6-108561279-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.812
- REVEL 0.81
- MetaLR 0.98
- MetaSVM 1.07
- CADD 26.30
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available
- Literature evidence available