K46E (p.Lys46Glu) variant of FOXO3 (Forkhead box protein O3)
K46E (p.Lys46Glu) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
K46E (p.Lys46Glu) variant details
- p.Lys46Glu
- TOPMed rs1409731500
- gnomAD rs1409731500
- Missense
- Variant Prioritization Score for Impact Estimate 0.382
- REVEL 0.28
- MetaLR 0.24
- MetaSVM -0.76
- CADD 21.80
- SIFT 0.17
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available