A45P (p.Ala45Pro) variant of FOXO3 (Forkhead box protein O3)
A45P (p.Ala45Pro) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
A45P (p.Ala45Pro) variant details
- p.Ala45Pro
- gnomAD rs1289813804
- Missense
- Variant Prioritization Score for Impact Estimate 0.414
- REVEL 0.24
- MetaLR 0.38
- MetaSVM -0.44
- CADD 21.90
- PolyPhen-2 0.14
- SIFT 0.10
- Most common in the Non-Finnish European population (allele frequency 9.2e-07)
- Structural context available