P38L (p.Pro38Leu) variant of FOXO3 (Forkhead box protein O3)
P38L (p.Pro38Leu) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.50 / 1. The record also includes population frequency data and structural context.
P38L (p.Pro38Leu) variant details
- p.Pro38Leu
- ExAC rs775459697
- TOPMed rs775459697
- gnomAD rs775459697
- Missense
- Variant Prioritization Score for Impact Estimate 0.497
- REVEL 0.38
- MetaLR 0.55
- MetaSVM -0.07
- CADD 23.30
- PolyPhen-2 0.00
- SIFT 0.02
- Most common in the Ashkenazi Jewish population (allele frequency 0.00029)
- Structural context available