S12F (p.Ser12Phe) variant of FOXO3 (Forkhead box protein O3)
S12F (p.Ser12Phe) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data, published literature, and structural context.
S12F (p.Ser12Phe) variant details
- p.Ser12Phe
- gnomAD 6-108561243-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.459
- REVEL 0.33
- MetaLR 0.36
- MetaSVM -0.27
- CADD 23.60
- PolyPhen-2 0.04
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 9.2e-07)
- Structural context available
- Literature evidence available