Q25K (p.Gln25Lys) variant of FOXO3 (Forkhead box protein O3)
Q25K (p.Gln25Lys) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data, published literature, and structural context.
Q25K (p.Gln25Lys) variant details
- p.Gln25Lys
- gnomAD 6-108561281-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.431
- REVEL 0.34
- MetaLR 0.60
- MetaSVM 0.14
- CADD 22.80
- PolyPhen-2 0.07
- SIFT 0.07
- Most common in the East Asian population (allele frequency 2.7e-05)
- Structural context available
- Literature evidence available