A42T (p.Ala42Thr) variant of FOXO3 (Forkhead box protein O3)
A42T (p.Ala42Thr) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
A42T (p.Ala42Thr) variant details
- p.Ala42Thr
- TOPMed rs1171605677
- Missense
- Variant Prioritization Score for Impact Estimate 0.372
- REVEL 0.24
- MetaLR 0.31
- MetaSVM -0.72
- CADD 20.90
- PolyPhen-2 0.00
- SIFT 0.12
- Most common in the Non-Finnish European population (allele frequency 9.2e-07)
- Structural context available