V16M (p.Val16Met) variant of FOXO3 (Forkhead box protein O3)
V16M (p.Val16Met) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.61 / 1. The record also includes population frequency data, published literature, and structural context.
V16M (p.Val16Met) variant details
- p.Val16Met
- gnomAD 6-108561254-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.614
- REVEL 0.52
- MetaLR 0.70
- MetaSVM 0.53
- CADD 23.80
- PolyPhen-2 0.45
- SIFT 0.03
- Most common in the African/African-American population (allele frequency 3.1e-05)
- Structural context available
- Literature evidence available