P44H (p.Pro44His) variant of FOXO3 (Forkhead box protein O3)
P44H (p.Pro44His) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data, published literature, and structural context.
P44H (p.Pro44His) variant details
- p.Pro44His
- gnomAD 6-108561339-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.486
- REVEL 0.37
- MetaLR 0.45
- MetaSVM -0.04
- CADD 22.60
- PolyPhen-2 0.21
- SIFT 0.02
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available