P5S (p.Pro5Ser) variant of FOXO3 (Forkhead box protein O3)
P5S (p.Pro5Ser) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data, published literature, and structural context.
P5S (p.Pro5Ser) variant details
- p.Pro5Ser
- gnomAD 6-108561221-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.287
- REVEL 0.20
- MetaLR 0.39
- MetaSVM -0.50
- CADD 16.10
- PolyPhen-2 0.00
- SIFT 0.16
- Most common in the Non-Finnish European population (allele frequency 9.3e-07)
- Structural context available
- Literature evidence available