S26C (p.Ser26Cys) variant of FOXO3 (Forkhead box protein O3)
S26C (p.Ser26Cys) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.50 / 1. The record also includes population frequency data and structural context.
S26C (p.Ser26Cys) variant details
- p.Ser26Cys
- cosmic curated COSV59631
- ExAC rs770706574
- gnomAD rs770706574
- Missense
- Variant Prioritization Score for Impact Estimate 0.496
- REVEL 0.43
- MetaLR 0.56
- MetaSVM 0.07
- CADD 25.80
- PolyPhen-2 0.57
- SIFT 0.01
- Most common in the HGDP:YORUBA population (allele frequency 0.25)
- Structural context available