P28S (p.Pro28Ser) variant of FOXO3 (Forkhead box protein O3)
P28S (p.Pro28Ser) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.59 / 1. The record also includes population frequency data, published literature, and structural context.
P28S (p.Pro28Ser) variant details
- p.Pro28Ser
- gnomAD 6-108561290-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.59
- REVEL 0.51
- MetaLR 0.60
- MetaSVM 0.37
- CADD 23.30
- PolyPhen-2 0.24
- SIFT 0.04
- Most common in the Non-Finnish European population (allele frequency 9.2e-07)
- Structural context available
- Literature evidence available