E17D (p.Glu17Asp) variant of FOXO3 (Forkhead box protein O3)
E17D (p.Glu17Asp) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data, published literature, and structural context.
E17D (p.Glu17Asp) variant details
- p.Glu17Asp
- gnomAD 6-108561259-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.302
- REVEL 0.22
- MetaLR 0.34
- MetaSVM -0.56
- CADD 16.80
- PolyPhen-2 0.00
- SIFT 0.59
- Most common in the Non-Finnish European population (allele frequency 9.2e-07)
- Structural context available
- Literature evidence available