R27L (p.Arg27Leu) variant of FOXO3 (Forkhead box protein O3)
R27L (p.Arg27Leu) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.66 / 1. The record also includes population frequency data, published literature, and structural context.
R27L (p.Arg27Leu) variant details
- p.Arg27Leu
- gnomAD 6-108561288-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.661
- REVEL 0.63
- MetaLR 0.73
- MetaSVM 0.43
- CADD 24.60
- PolyPhen-2 0.23
- SIFT 0.00
- Population evidence available
- Structural context available
- Literature evidence available