A6T (p.Ala6Thr) variant of FOXO3 (Forkhead box protein O3)
A6T (p.Ala6Thr) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data, published literature, and structural context.
A6T (p.Ala6Thr) variant details
- p.Ala6Thr
- gnomAD 6-108561224-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.335
- REVEL 0.24
- MetaLR 0.25
- MetaSVM -0.84
- CADD 21.80
- PolyPhen-2 0.00
- SIFT 0.50
- Most common in the East Asian population (allele frequency 2.8e-05)
- Structural context available
- Literature evidence available