P44L (p.Pro44Leu) variant of FOXO3 (Forkhead box protein O3)
P44L (p.Pro44Leu) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
P44L (p.Pro44Leu) variant details
- p.Pro44Leu
- gnomAD rs1221996251
- Missense
- Variant Prioritization Score for Impact Estimate 0.428
- REVEL 0.27
- MetaLR 0.47
- MetaSVM -0.06
- CADD 19.80
- PolyPhen-2 0.01
- SIFT 0.12
- Most common in the REMAINING population (allele frequency 0.00048)
- Structural context available