P44A (p.Pro44Ala) variant of FOXO3 (Forkhead box protein O3)
P44A (p.Pro44Ala) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data, published literature, and structural context.
P44A (p.Pro44Ala) variant details
- p.Pro44Ala
- gnomAD 6-108561338-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.354
- REVEL 0.22
- MetaLR 0.37
- MetaSVM -0.49
- CADD 15.50
- PolyPhen-2 0.00
- SIFT 0.62
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- Literature evidence available