E21K (p.Glu21Lys) variant of FOXO3 (Forkhead box protein O3)
E21K (p.Glu21Lys) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.58 / 1. The record also includes population frequency data, published literature, and structural context.
E21K (p.Glu21Lys) variant details
- p.Glu21Lys
- gnomAD 6-108561269-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.584
- REVEL 0.56
- MetaLR 0.47
- MetaSVM 0.00
- CADD 25.20
- PolyPhen-2 0.04
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9.2e-07)
- Structural context available
- Literature evidence available